Karyomegalic Interstitial Nephritis
نویسندگان
چکیده
منابع مشابه
Karyomegalic Interstitial Nephritis
Karyomegalic interstitial nephritis is a rare cause of hereditary chronic interstitial nephritis, described for the first time over 40 years ago.A 36-year-old woman, of Turkish origin, presented with chronic kidney disease and high blood pressure. She had a history of recurrent upper respiratory tract infections but no familial history of nephropathy. Physical examination was unremarkable. Labo...
متن کاملKaryomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice.
The Fan1 endonuclease is required for repair of DNA interstrand cross-links (ICLs). Mutations in human Fan1 cause karyomegalic interstitial nephritis (KIN), but it is unclear whether defective ICL repair is responsible or whether Fan1 nuclease activity is relevant. We show that Fan1 nuclease-defective (Fan1(nd/nd)) mice develop a mild form of KIN. The karyomegalic nuclei from Fan1(nd/nd) kidney...
متن کاملInterstitial nephritis.
The clinical and pathological findings are reviewed in ten cases where renal biopsy showed abnormalities predominantly within the interstitium. In six the nephritis was considered to be drug-induced; in two the aetiology was slightly obscure but the most likely diagnosis was considered to be sarcoidosis. Of the remaining two cases one was chronic pyelonephritis and the other polyarteritis nodos...
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Citation for published version: Zhou, W, Otto, EA, Cluckey, A, Airik, R, Hurd, TW, Chaki, M, Diaz, K, Lach, FP, Bennett, GR, Gee, HY, Ghosh, AK, Natarajan, S, Thongthip, S, Veturi, U, Allen, SJ, Janssen, S, Ramaswami, G, Dixon, J, Burkhalter, F, Spoendlin, M, Moch, H, Mihatsch, MJ, Verine, J, Reade, R, Soliman, H, Godin, M, Kiss, D, Monga, G, Mazzucco, G, Amann, K, Artunc, F, Newland, RC, Wiech...
متن کاملGranulomatous interstitial nephritis.
Granulomatous interstitial nephritis (GIN) is a rare histologic diagnosis. This series reports the presenting features, associated conditions, treatment, and outcome of patients with a diagnosis of GIN in Glasgow during a 15-yr period and compares this with the available literature. Eighteen cases were identified: Five cases were associated with sarcoidosis, two were associated with tubulointer...
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ژورنال
عنوان ژورنال: Medicine
سال: 2016
ISSN: 0025-7974
DOI: 10.1097/md.0000000000003349